This study targeted the concentrations of heavy metals (iron, manganese, copper, and zinc) in wastewater sources in Kafr El-Sheikh Governorate, Egypt, and proved their presence in different concentrations of heavy metals (Fe, Mn, Cu, and Zn) concentrations in wastewater at Kafr El-Sheikh Governorate, Egypt, and proved their existence with different concentrations. Numerous microalgae were found to significantly remediate different heavy metals from wastewater. Within the study's conclusions were the isolation and identification of Pseudoanabaena mucicola under accession OR143298 for the remarkable capability of, chemical oxygen demand (COD), total soluble solid (TSS), total dissolved salts (TDS), biological oxygen demand (BOD) and heavy metals (Fe, Mn, Cu, and Zn) removal from wastewater at 28 ͦC and different pH (7, 8 and 9) for 1-4 weeks. The decreasing capacity by P. mucicola were 90.03% for chemical oxygen demand (COD), 42.95% total dissolved salts (TDS), 89.88% biological oxygen demand (BOD), and increasing the TSS by 125.83% after 4 weeks. P. mucicola absorbs 100% Fe from wastewater after 3 weeks, Mn from wastewater after 2 weeks, Cu, and Zn from wastewater after 1 week, respectively. The results that were presented showed how promising P. mucicola is for absorbing heavy metals (Fe, Mn, Cu, and Zn) from wastewater.