To solve rising fertilizer costs and preserve environment from pollution in addition decrease mineral fertilization with using organic fertilizers on leafy vegetables that used in salad, a field experiment was done to investigate the impact of irrigation treatments (magnetized water and normal water) and different rates of N and vermicompost fertilizers (100% N, 75% N + 25% vermicompost, 50% N + 50% vermicompost, 25% N + 75% vermicompost and 100% vermicompost) on crisphead lettuce growth and quality. The results cleared that irrigation with magnetized water gave the highest values of vegetative growth, ion concentrations, yield and quality. Furthermore, crisphead lettuce fertilized with 50% N + 50% vermicompost exhibited the highest vegetative growth, yield, chlorophyll contents and Mg percentage, while plants fertilized with 75% N + 25% vermicompost gave the highest quality of crisphead plants. Thus, it is recommended that irrigate crisphead lettuce with magnetized water and fertilized plants with 50% N + 50% vermicompost. This treatment can help decrease production costs by 50% with high yield.