This paper inspects the application of antiseptics among university pupils in Egypt. A questionnaire design aims to assess pupils' knowledge, stations, and recent use of antibiotics in the last 6 months. It set up that nearly half of the scholars used antibiotics, and worryingly a quarter did so without a tradition. The most common reasons for taking antibiotics are fever, pain, and inflammation. This study delved scholars' knowledge and stations toward antibiotics. Antibiotics are antimicrobial substances that fight bacterial infections. It's a great medical invention but overuse can beget resistance. It can lead to worse health issues similar as infections with resistant bacteria and longer sanatorium stays. This is because cases with reported disinclinations may admit indispensable antibiotics that have further side goods. It's important to use antibiotics wisely to avoid these serious problems. Antibiotics work in different ways to kill or inactivate bacteria. Antibiotic resistance is a growing trouble, caused by the overuse and abuse of antibiotics. This abuse can be in hospitals, conventions and the food assiduity. Antibiotic resistance makes infections more delicate to treat and can lead to the spread of dangerous bacteria. Multidrug- resistant organisms (MDROs) is bacteria that is impervious to multiple antibiotics. Abuse of antibiotics and sanatorium settings promotes the growth of MDRO. exemplifications include the following MRSA and VRE. The World Health Organization and the Centres for Disease Control and Prevention have plans to combat the spread of these medicines.