Digestive problems in dogs are one of the most important causes of presentation to clinicians. Vomiting and diarrhea can cause severe mucosal damage which may alter the digestion and absorption of different nutrients. This study was to determine the hemato-biochemical condition, some macro-minerals and trace-elements status in dogs with vomiting, diarrhea and concurrent vomiting and diarrhea. Results showed significant increase in respiration, pulse and temperature. Hematological examination revealed significant decrease in RBCs count while significant increase in red cell indices and WBCs count. Differential leukocytic count showed significant increase in neutrophils and eosinophils in cases with diarrhea and concurrent vomiting with diarrhea while there was significant decrease in relative lymphocytes in cases with concurrent vomiting and diarrhea. Biochemical examination showed significant decrease in serum copper and zinc in all diseased groups while there was non-significant change in the serum levels of sodium, potassium and total serum iron.