In the present study, the growth parameters and immunostimulation were investigated in Oreochromis niloticus receiving diet supplemented with 1% crude ethanol Aloe vera extract and 1% Aloe vera gel compared with control fed on basal diet without any additives for 8 weeks. The results indicated significant increase in growth parameters namely weight gain (WG), Absolute growth rate (AGR), Specific growth rate (SGR), Feed conversion rate (FCR) and Feed efficiency rate (FER). Also an increase in non-specific immune response was detected in vitro phagocytic activity test with significant increase in total protein and globulin.The results also indicated an increase in anti-oxidant effect detected by catalase activity