Artichoke by-products are a promising and cheap source of bioactive compounds and represent a potential alternative to synthetic antioxidants. This study was conducted to determine the total phenolics, flavonoids concentration and antioxidant activities of the non-edible parts (leaves, stems and outer bracts) from two taxa Egyptian ''Baladi'' and French ''Hyrious'' artichoke. The results demonstrated that the bioactive compounds and antioxidant activity in stems of the Egyptian ''Baladi'' are higher than the French ''Hyrious''. The highest flavonoids concentration were recorded in the stems of both cultivars (81.36 and 83.10 mgQE/gDW). Whereas, the outer bracts of both cultivars of artichoke contain the highest levels of the antioxidant capacity (116.66 and 112.90 mgAE/gDW), and highest concentration of total phenolics (5.02 and 4.90 mgGA/gDW). However, leaves and outer bracts of French ''Hyrious" show higher concentration of the total phenolics, flavonoids, and antioxidant activity than Egyptian ''Baladi''. In addition, the results proved the linear correlation between the total phenolics and the antioxidant activity. Moreover, the levels of the bioactive compounds exhibited higher than the reported in the literature. Therefore, the use of non-edible parts of Egyptian artichoke could be an environmentally friendly natural source of phenolics, antioxidants, and flavonoids for the health benefits and an economically viable solution to the problem of solid waste treatment.