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237661

PROTECTIVE EFFECT OF AVOCADO FRUIT (Persea americana) POWDER AND EXTRACT AGAINST HEPATIC INJURY IN EXPERIMENTAL RATS

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Last updated: 05 Jan 2025

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Abstract

The purpose of this study was to investigate the protective efficacy of avocado fruit (Persea americana) powder and extract against paracetamol induced hepatic injury in rats. Forty male Sprague-Dawley rats weighing (115 ± 10) (8 rats), were divided into five groups: normal control group (-ve), paracetamol control  single dose of (2 g/kg/b.wt/rat) as control (+ve), and the other three treated groups were with 5 g/kg/diet/day avocado powder, 0.5 ml /kg/ b.wt/ rats/day avocado extract by stomach tube and mixture with 5 g/kg/diet/day avocado powder and 0.5 ml /kg/ b.wt/ rats/day avocado extract. The result revealed that all of the treated groups showed significant increase in body weight gain, serum HLDL-C, total protein, total antioxidant capacity, SOD levels. Moreover, significant decrease serum TC, TG, LDL-C, VLDL-C, AST, ALT, alkaline phosphotase enzymes (Alk-Pho), total bilirubin and nitric oxide (NO) in comparing to positive control group. The current study suggests that avocado powder and extract may be content of the phytochemical such as tannins, saponins, glycoside, flavonoids and carbohydrates beneficial as a protective antioxidant supplement with promising antioxidant potential to combat paracetamol induced hepatic injury in rats.

DOI

10.21608/jsezu.2015.237661

Keywords

Persea americana, Paracetamol, Hepatotoxicity, Phytochemical

Authors

First Name

Mhasin

Last Name

Ali Kotb

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Volume

1

Article Issue

2

Related Issue

34095

Issue Date

2015-07-01

Receive Date

2022-05-17

Publish Date

2015-07-01

Page Start

213

Page End

230

Print ISSN

2356-8690

Article File

JSEZU_Volume 1_Issue 2_Pages 213-230.pdf

PDF . 814.9kB

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https://jsezu.journals.ekb.eg/article_237661.html

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https://jsezu.journals.ekb.eg/service?article_code=237661

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237,661

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المقالة الأصلية

Type Code

2,139

Publication Type

Journal

Publication Title

مجلة دراسات وبحوث التربية النوعية

Publication Link

https://jsezu.journals.ekb.eg/

MainTitle

PROTECTIVE EFFECT OF AVOCADO FRUIT (Persea americana) POWDER AND EXTRACT AGAINST HEPATIC INJURY IN EXPERIMENTAL RATS

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Article

Created At

23 Jan 2023