In recent years, the willow (Salix safsaf), is widely distributed along 
the River Nile in Egypt, leaves used as a traditional medicine. Thus, 
the objective of this study was to evaluate the healthy drinks from 
dried willow leaves, as well as, its water extracts, as natural 
antioxidant and antimicrobial agents as well as protection from 
thrombosis. The leaves of willow were dried with three methods;
oven, sun and vacuum drying. The methanolic extract of vacuum 
drying leaves gave the highest concentrations of phenolic and 
flavonoid compounds. The resultant of different dried Willow leaves 
(Salix safsaf) was evaluated for their proximate composition (on dry 
weight basis), Besides, DPPH, total phenolic compounds and total 
flavonoid. Results of the proximate analysis revealed that the moisture 
content recorded 5.95 ,5.48 ,7.26% in oven, sun and vacuum drying, 
respectively, whoever ash and fibers were 0.42& 1.22, 0.34& 1.5, 2.04 
and 2.23% in oven, sun and vacuum drying, respectively. Chlorophyll 
a and b contents were 3.12&12.64, 1.52 &5.88 and 3.42& 14.19 in 
samples dried by oven, sun and vacuum drying, respectively.