Nutrition health is very important component in control of infectious diseases severity. Better 
nutrition is related to improved infant, child and maternal health, stronger immune systems, lower 
risk of non-communicable diseases (NCDs), and longevity. The current review shows the bioactive 
compounds, applications and potency of extra virgin olive oil (EVOO) as nutritional therapeutic 
immune-enhancer with evidence-based health benefits confirmed by scientific research works. The 
extensive literature survey revealed that EVOO is used for the treatment of stomach problems, 
diabetes, hypertension, diarrhea, respiratory and urinary tract infections, skin diseases, bacterial 
and fungal infections, hemorrhoids, rheumatism, asthma, and hair loss. Recent studies have been 
carried out focusing on evaluation of the antidiabetic, anticancer, antimicrobial, antifungal, 
antiviral, antioxidant, antihypertensive, gastroprotective, anti-inflammatory, antinociceptive, 
neuroprotective, and cardioprotective activities. EVOO as a valuable component of Mediterranean 
diet (MED), can help keep immune system strong and reduce the inflammation and oxidative stress 
that lead to a variety of diseases and conditions that increase risk for serious cases of COVID-19.