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197845

ANTIBACTERIAL ACTIVITY OF FUROQUINOLONE ALKALOIDS AGAINST POTATO SOFT ROT BACTERIUM, Erwinia carotovora FROM Ruta chalepensis LEAVES

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Last updated: 05 Jan 2025

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Abstract

Soft rot bacterium; Erwinia carotovora is one of the most
severe post-harvest diseases of potatoes worldwide. This bacterium
affects tubers during storage, transit and marketing. The aqueous
ethanolic extract (80%) of Ruta chalepensis leaves (Rutaceae)
showed antibacterial activity against Erwinia carotovora (MIC =
625 µg/ml). Bioassay-guided isolation of this aqueous extract by
using a combination of different chromatographic methods (TLC
and column chromatography) yielded two furoquinolone alkaloids
for the first time from this plant. Their structures were
characterized as 2, (hydroxy isopropyl) – 6, hydroxy –9, methyldihydrofuro [2,3] –quinol-4-one (I) and 3, (hydroxy methyl)-6,
methoxy-2, 2, 9-trimethyl-dihydrofuro [2,3] quinol-4-one (II) by
1
H, 13C NMR and MS spectral data. The isolated alkaloids I and II
showed antibacterial activity against Erwinia carotovora with MIC
at 20 and 35 µg/ml respectively.

DOI

10.21608/fjard.2005.197845

Keywords

Furoquinolone alkaloids, Soft rot bacterium, Ruta chalepensis, Rutaceae and Erwinia carotovora

Authors

First Name

Ahmed M.

Last Name

Emam

MiddleName

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Affiliation

Biochemistry Department, Faculty of Agriculture, Fayoum Branch, Cairo Univ., Egypt.

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Orcid

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First Name

Mohamed E.

Last Name

Mahmoud

MiddleName

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Affiliation

Botany Department (Microbiology), Faculty of Science, Cairo Univ., Giza, Egypt.

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Volume

19

Article Issue

2

Related Issue

27974

Issue Date

2005-07-01

Receive Date

2021-10-03

Publish Date

2005-07-01

Page Start

191

Page End

202

Print ISSN

1110-7790

Online ISSN

2805-2528

Article File

FJARD_Volume 19_Issue 2_Pages 191-202.pdf

PDF . 865.7kB

Link

https://fjard.journals.ekb.eg/article_197845.html

Detail API

https://fjard.journals.ekb.eg/service?article_code=197845

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17

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Research articles.

Type Code

1,920

Publication Type

Journal

Publication Title

Fayoum Journal of Agricultural Research and Development

Publication Link

https://fjard.journals.ekb.eg/

MainTitle

ANTIBACTERIAL ACTIVITY OF FUROQUINOLONE ALKALOIDS AGAINST POTATO SOFT ROT BACTERIUM, Erwinia carotovora FROM Ruta chalepensis LEAVES

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Article

Created At

23 Jan 2023