The present study was conducted in Shakshouk Fish Research Station, Fayoum Governorate, National Institute of Oceanography and Fisheries (NIOF), Egypt in 2019 for 93 days experimental period by using 5 treatment of Red tilapia ponds (10 fish/pond). A ponds were consumed the same artificial diets (27% CP). 1 cm/m³ from each treatment was added at the beginning and repeated every month to ponds. The treatments were control treatment (without adding), Yeasts, Bacillus sp., Pseudomonas sp. and lactic acid bacteria. The results revealed that survival rate was insignificant, but lower than normal 72.2–83.3 %.The highest final weights of red tilapia (P£0.05) were recorded with Pseudomonas sp.  treatment and the lowest was the recorded with control group. Wight gain, daily gain and specific growth rate was recorded a significant effects, where the best treatments was found with Bacillus sp., Significant differences (P£0.05) were obtained in all feed utilization, except the feed intake. The best FCR (lowest) was recorded with lactic acid treatments.The worst FCR was recorded with control group.Heavy metal concentration analysis in water showed the less values with yeast treatment, Bacillus sp., and lactic acid bacteria and these treatments appears improvement on growth performance and feed utilization. Ammonia and nitrite was shown the lowest values with the pond treated with Bacillus sp., but the higher values of ammonia was recorded significant effects with yeast treatment. Kidney and liver functions showed the lowest values with control group, but higher with yeast treatments.