270055

Sensitivity analysis of longitudinal data with intermittent missing values: Application in a clinical trial

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Last updated: 05 Jan 2025

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Abstract

We conduct two types of sensitivity analyses of study conclusion , in intermittent setting : the first is fitting different to the response variable. The marginal distribution of the response is assumed to be ekewed distribution, the lognormal distribution in particular. The second is fitting several models for the missing data mechanism, for example, modeling the missingness based on a generalized linear model, with logic and probit link function. The model can be extended to permit possible relationships between the missing data process and covariates, for example time. The selection model for incomplete longitudinal data is presented. The stochastic EM algorithm is proposed and developed for skewed distribution model, the lognormal distribution in particular. Models for the missing data mechanism are presented. The proposed methods are applied to a data set from the international Breast Cancer Study Group.

DOI

10.21608/esju.2017.270055

Volume

61

Article Issue

1

Related Issue

33785

Issue Date

2017-06-01

Receive Date

2017-04-16

Publish Date

2017-06-01

Page Start

1

Page End

14

Print ISSN

0542-1748

Online ISSN

2786-0086

Link

https://esju.journals.ekb.eg/article_270055.html

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https://esju.journals.ekb.eg/service?article_code=270055

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1

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Original Article

Type Code

1,914

Publication Type

Journal

Publication Title

The Egyptian Statistical Journal

Publication Link

https://esju.journals.ekb.eg/

MainTitle

Sensitivity analysis of longitudinal data with intermittent missing values: Application in a clinical trial

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Article

Created At

23 Jan 2023