The present investigation was carried out to clearify the efficacy of Ranide; Dovenix and Bilevon in treatment of Fascioliasis. The results revealed no eggs in feaces of infested animals after 2-3 weeks post treatment. The results of biochemical studies revealed hypoalbuminaemia, hyperglobulonaemia, decrease in A/G ratio and an increase in total bilirubin of blood serum of fasciola infested animals. All parameters were progressed to normal levels with the progress towards recovery.