Thirty native Balady sheep infested with Fasciola gigantica at Assiut province and 10 healthy control (1-4 years age, 60-90 kg. b.wt) were used in the study to investigate the clinical signs of chronic ovine fasciol iasis and the effect of Flukanide (7.5% rafoxanide) and Bilevon-M (75 mg tablets of niclofolan) on the parasite. The study cleared that Flukanide was more effective and more suitable for treatment of sheep liver flu ke than Bilevon-M. The examination of the treated animals did not show any Fasciola gigantica eggs in their faeces after 4 and 8 weeks post treatment by Flukanide and Bilevon-M respectively as shown by concentration floatation technique. Flukanide could be injected S/C safely without any pre- or post-treatment precautions.