Dermatophilosis is a bacterial disease affecting wide range of animal species in addition to humans. The clinical picture of the disease was studied in a flock of sheep and goats (86 and 22 respectively) and herd of cattle and buffaloes (62 and 34 respectively). The clinical picture was in the form of skin lesions which varied in its severity and distribution owing to species affected. In sheep, the lesions were in the form of irregular area of alopecia with crust formation in the face, ears and legs from the coronet to the knees. Matted, broken or easily detached wool is recorded. The lesions were similar in goats while in cattle the lesions were distributed on the skin of chest and abdomen. In buffaloes it was confined on the distal portion of the legs. Out of the diseased sheep, 18 were classified into 3 groups each of six animals. The first group were treated parentrally using long acting oxytetracycline. Those of the second group were treated topically using garlic oil. The 3^rd group was treated both parentally and topically. It was noticed that garlic oil is highly efficient in treatment of dermatophilosis.