Total serum immunoglobulins, IgG, IgM and IgA levels were estimated in 60 newly born buffalo calves at 2^nd day of age, belonged to a private dairy farm in Sharkia governorate. The relation between these levels and the subsequent occurrence of some disease conditions in the first two months of life was observed. All calves received colostrum by natural suckling and their health were monitored from birth to 60 days age. The total serum immunoglobulins concentrations was measured by sodium sulphite precipitation test (S.S.P.T.), while, the serum level of immunoglobulin classes (IgG, IgM and IgA) was measured by a single radial immunodiffusion test (S.R.I). The results revealed that, 14 of examined calves (23.33%) suffered from undifferentiated diarrhea, 9 suffered from pneumonia (15%), while 37 of calves (61.66%) remained healthy. A positive correlation was observed between immunoglobulins levels and the health of the animals. Healthy calves had higher levels of total immunoglobulins compared to those which developed diarrhea or pneumonia. In conclusion, there is an association between failure of passive transfer of colostral immunoglobulins in calves and susceptibility to neonatal diseases. This failure, which is reflected by low serum immunoglobulins levels, is one of the most important influencing factors in mortality of newly born calves.