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177392

STUDIES ON RIFT VALLEY FEVER VACCINE ADJUVANTED WITH ALUMINIUM PHOSPHATE

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Last updated: 28 Dec 2024

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Abstract

Seventeen Balady sheep were used in this investigation. The animals were divided into 6 groups, the first group (G1) was vaccinated subcutaneously (S/C) with binary inactivated Rift Vally Fever (RVF) vaccine with 1.00% aluminium phosphate, the second group (G2) was vaccinated S/C with binary inactivated RVF vaccine with 0.75% aluminium phosphate, the third group (G3) was vaccinated S/C with binary inactivated RVF vaccine with 0.50% aluminium phosphate, the fourth group (G4) was vaccinated S/C with binary inactivated RVF vaccine with 0.25% aluminium phosphate, the fifth group (G5) was vaccinated S/C with inactivated RVF vaccine with 2% aluminium hydroxide gel while the sixth group (G6) left as control. The results revealed that group (1) followed by group (2) gave higher level of antibody and reaching its protective level earlier than RVF inactivated vaccine with aluminium gel and the duration of immunity of aluminium phosphate when compared with that of aluminium hydroxide is mush longer. In addition, the best vaccine was RVF inactivated vaccine containing 1.00% aluminium phosphate followed by RVF inactivated vaccine containing 0.75% aluminium phosphate as they gave higher level of antibody all over the period of the test compared with that of other vaccinated groups when tested by serum neutralization test and ELISA test. Moreover, manufacturing of these vaccines is easy to be done and of low cost.

DOI

10.21608/avmj.2006.177392

Keywords

Key words: Rift valley fever, Vaccination, Virology

Authors

First Name

LILY

Last Name

SOBHY SALAMA

MiddleName

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Affiliation

Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo

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Orcid

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Volume

52

Article Issue

110

Related Issue

24395

Issue Date

2006-07-01

Receive Date

2021-05-02

Publish Date

2006-07-01

Page Start

158

Page End

171

Print ISSN

1012-5973

Online ISSN

2314-5226

Link

https://avmj.journals.ekb.eg/article_177392.html

Detail API

https://avmj.journals.ekb.eg/service?article_code=177392

Order

14

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

STUDIES ON RIFT VALLEY FEVER VACCINE ADJUVANTED WITH ALUMINIUM PHOSPHATE

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Article

Created At

23 Jan 2023