A total of six healthy goat kids were used in this investigation to study some physiological and anaesthetic effects of Thiopentone sodium at doe level of 10 mg/kg i/v in animals premedicated with acepromazine or diazepam or xylazine and non premedicated animals. Usages of premedication lead to smoother induction of anaesthesia rather than non premedicated animals. Apnoea occurred in the different groups used in this study with significant prolongation in the group anaesthetized with Thiopentone sodium with Xylazine. Respiratory rate, heart rate and rectal temperature were affected to different limits. Usage of the three different premedication drugs especially Xylazine hydrochloride lead to improvement of Thiopentone sodium anaesthetic effects.