This study was conducted using 18 clinically healthy desert goats          (6 females and 12 males) to study the effect of increasing the dose of Thiopentone sodium on some physiological and anaesthetic parameters. Thiopentone sodium was used at three different dose levels (10, 15 and 20mg/kg body weight) 2.5% solution. Increasing the dose of Thiopentone sodium resulted in an increase in the duration of the different anaesthetic phases. This increase might be in terms of duration of the phase or percentage of the phase to the total recovery time. Respiration and heart rate were affected significantly (P<0.05) as a result of using Thiopentone sodium at the three different levels. Rectal temperature was affected non- significantly in the three groups.