Administration of urea orally at a dose of 0.5 mg/kg body weight to sheep has resulted in depression, dehydration, muscle tremors and convulsions. Those signs were interrupted by intravenous administration of 1mg/kg furosemide and normal saline resulting in fast recovery of animals. Animals dosed with urea showed higher haematocrit values and higher ammonia, urea, glucose and creatinine compared with controls. Treatment with furosamide and fluid therapy has significantly produced lower haematcrit values and ammonia, urea, glucose and ceatinine levels