The reproductive performance following oestrus synchronization and artificial insemination (AI) was evaluated during autumn and early winter in 60 Nubian goats in the Sudan to determine the best hormonal approach in inducing and synchronizing oestrus. The animals were divided into 4 groups (A–D).  All goats, except the control group, were synchronized for 12 days with flourogestone acetate (FGA) sponges followed by an IM injection of equine chorionic gonadotropin (eCG) or cloprostenol (PGF2α) at progestagen withdrawal. Cervical artificial inseminations (AI) were performed at 48 h after FGA withdrawal using fresh diluted semen. Results obtained indicated that all hormonal treatments used were efficient to induce and synchronize oestrus in Nubian goats. However, the response in treatment B and treatment C (FGA and FGA/eCG) were higher (80%) than FGA/PGF2α treatment (65%). Animals treated with FGA/eCG recorded higher pregnancy rate (45%) and kidding rate (35%). The fertility as indicated by pregnancy and kidding rates was lower in animals treated with FGA/PGF2α and in the control group. In the present study, kidding rate, fecundity, twining rate and gestation length were not significantly affected by synchronization methods. Therefore, the use of progestagen sponges with or without eCG or PGF2 α was effective in induction and synchronization of oestrus in Nubian goats.