The objective of this study was to investigate the effect watery extract of Artemisia herba alba on blood glucose level and body weight in alloxan - diabetic rabbits. The experiment was carried out on 18 male rabbits (1.3 – 1.5 kg/ b.wt.) distributed into 3 groups, of 6 animals each. The 1^st group was kept as normal control, while the 2^nd and 3^rd groups were rendered diabetic by intraperitoneal injection of alloxan (150 mg/kg b.wt.). The 2^nd group was left as diabetic control, while the 3^rd group was given orally the watery extract of Artemisia herba in a dose of 400 mg/kg b.wt./day for 3 weeks. Blood samples were collected for determination of glucose levels and rabbits were weighed at the beginning and end of the experiment. The obtained results showed that oral administration of Artemisia herba watery extract to diabetic rabbits significantly (p> 0.05) decreased the high blood glucose level and increased body weight of the treated diabetic rabbits, as compared to the diabetic control group. In conclusion Artemisia herba watery extract produces antidiabetic effect in alloxan - diabetic rabbits and it may be beneficial for patients who suffer from diabetes mellitus.