This study was carried out on 103 heads of pregnant Awasi sheep during the months of December and January of 2008/2009. The concentrations of Glucose, β- Hydroxy biotyrate (βHB), Non esterified fatty acids (NEFAs), Urea, Total Bilirubin, Total Protein, Alanine aminotransferase (ALT),Aspartate aminotransferase (AST), Ca, P, were all tested. It was shown from the results that there was significant increase of βHB, NEFAs, Urea, T. Bili., AST, and ALT. There was significant decrease of Glucose, T. Protein in blood serum (value of P < 0.0005) but there was insignificant changes in Ca, P value between control and affected animals. These results were discussed in the shadow of previous related studies.