Twenty four (15 male and 9 female) albino rabbits were used for studying the effect of chronic sodium fluoride (NaF) administration in drinking water (7 and 10 mg/kg body wt/day) for 12 weeks on fertility. Animals showed signs of intoxication and finally paralysis. Histopathological examination of testis revealed mild to severe disorganization and denudation of germinal epithelial cells with complete absence of sperms and reduction of spermatogenesis as well as intraluminal multinucleated spermatides. NaF has permanent and irreversible effect after the withdrawal period. Inflammatory and degenerative changes were observed in both ovaries and uteri. Chronic fluorosis had carcinogenic effect on uterus as endometrial hyperplasia with solid type of clear cell adenocarcinoma and also on liver. It had a fetotoxic effect resulting in a significant reduction in pregnancy rate and the number of viable feoti in treated groups. In addition to, it induced pathological changes in liver, intestine, kidney, lung, heart and brain as well as spleen. We concluded that the degree of histopathological damages of different tissues seemed to be directly proportional to the dosage of fluoride.