A trial was carried out to study the effect of using two different  nutrients density broilers diets. Four thousand one day-old chicks of commercial meat line (ROSS308) were used in the trial. The birds were distributed into two groups of 2000 birds each, the first group fed with diets according to Syrian feed tables and the second one fed with diets according to NRC, (1994). The experiment lasted for 5 weeks. RBC count, WBC count, hemoglobin concentration, packed cell volume at 21and 35 days was estimated. Serum biochemical parameters at 21and 35 days, weight immune organs were also investigated and immune response against ND vaccinations at 21, 35 and days was carried out. Results showed as follows: Using diets according to NRC, (1994) achieved the better growth speed and FCR than diets according to Syrian feed tables. There are no significant differences in RBC count, WBC count, hemoglobin concentration, packed cell volume at 21and 35 days of age. There are no significant differences in serum biochemical parameters at 21and 35 days of age. There are no significant differences in weight of immune organs and immune response against ND vaccinations at 21, 35 days of age. There were no negative effects of using diets according to Syrian feed tables on blood profile, serum biochemical parameters and humoral immune responses.