This study aimed to demonstrate the pathological changes of the liver of cow and calves slaughtered in Alexandria governorate caused by fasciola. In the present investigation, the affection rate of the liver by fasciola was high. Post mortem examination of affected liver revealed two stages of infection, early stage directly seen as a result of primary infection and the progressive stage as a result of untreated cases or repeated infection. The gross hepatic lesion revealed shrinkage in size especially in the affected lobe with irregular surface and the fluke could be demonstrated in the bile duct. The histo-pathological examination showed coagulative necrosis and heamorrge in hepatic parenchyma, and the hepatic lobule lost its architecture, progressively increasing cellular infiltration especially eosinophil, lymphocyte and macrophage, the proliferation of bile ductules and fibrosis which occurred in adjacent portal triads and interlobular septa. Economic significance of fasciola is mainly due to direct losses caused by decrease of the weight rate, milking capacity and condemnation of altered livers in slaughter house.