The effect of aspirin and heparin on clotting factors indices in equine infected with babesiosis and treated with imidocarb dipropionate have been evaluated. Fifteen clinically diseased horses (3-5 years old) and from both sexes were used in this study. Infection with Babesia spp confirmed by clinical and laboratory diagnosis. Five clinically healthy horses were served as control. Horses were divided randomly into four groups. Of these control group were included clinically healthy horses. Imidocarb group which was treated with imidocarb dipropionate at a dose rate of 4 mg/kg BW injected intramuscular and repeated after 48h. and Aspirin group which was treated with imidocarb dipropionate at dose rate of 4mg/kgBW injected intramuscular and repeated after 48 h, and aspirin at dose rate of 10mg/kg BW by intramuscular injection repeated after 48 and 72h. Heparin group were treated with imidocarb dipropoinate at dose rate of 4mg/kgBW intramuscular repeated after 48h and heparin at dose rate of 100 I.U./kgBW S.C repeated after 48 and 72h, Samples were taken in 7th and 14th days after treatments. Results indicated significant increase in total platelets count and fibrinogen with significant decrease in platelets volume, platelets distribution width, clotting time, prothrombin time and activated partial thromboplastin time in heparin and aspirin group during the first and second week after treatment respectively and lasted to the end of experiment.With respect to hemogram there was a significant increase in TRBs, HB and PCV in all groups during the first week after treatment. Moreover parasitemia were significantly decreased to zero at the first week after treatment. Results also indicated significant decrease in total leukocytes count and lymphocytes with significant increase in nutrophiles during the first week after treatment. It have been concluded that heparin can degrade clotting factors indices in equine affected with babesisosis and might protected them from disseminating intravascular coagulopathy.