This study was carried out on ninety slaughtered camels of different ages and sex in Bani-Adi abattoir at Assiut Goverenorate. The clinical examination before slaughter proved that 25 camels had respiratory affections (Dyspnoea, cough, harried respiration and mucoid nasal discharge) and the remaining were apparently healthy clinically served as control group. 100 samples (25 nasal swabs and 25 from each of lung, pulmonary lymph nodes and pleural fluid)  were tested for bacteriological examination from  diseased \camels.Also in clinically healthy camels 65 nasal swabs were taken before slaughter for bacteriological examination. 103 (62.42%) samples were culturally positive for different microorganisms, from which 20 (30.76%) nasal swabs from clinically healthy camel. Bacteriological examination revealed that the main isolates were Staph. aureus 47 (45.63%), Strept. pyogenes 17 (16.50%), Klebsiella species 2 (71.97%) and Staph. epidermidis 17 (16.50%). The isolated E.Coli strains were identified serologically into 15 (14.55%) E.coli strain (O₁₂₆/B₆) and 5 (4.35%) untypable. Blood samples from clinically healthy and diseased animals were taken before slaughter for biochemical analysis. It showed that highly significant (P < 0.01) decrease in iron level, while there was a highly significant increase in copper levels in case of clinically diseased camels in comparison with healthy ones. Also, the study comprises the effect of bacterial respiratory affection of camels on blood gases and acid-base balance. There were a marked decrease in blood pH value and base excess (B.E), while significant decrease in Po₂ value as well as there is significant increase in PCo₂ value in clinically diseased camels in comparison with healthy ones. Antibiotic sensitivity tests for the isolated bacteria revealed that Garamycin is the best sensitive antibiotic of choice.