The objective of this study was to investigate the effect of alcohol extract of Cichorium Intybus on blood glucose and total cholesterol levels in alloxan- diabetic rabbits. The experiment was carried out on 18 rabbits of both sexes and body weight ranged between 2300- 2500 g b.wt. Rabbits were divided into 3 groups of 6 animals each. The 1^st group was kept as a normal control, while rabbits of the 2^nd and 3^rd groups were rendered diabetic by intraperitoneal injection of alloxan in a dose of 150 mg/kg b.wt. The 2^nd group was left as a diabetic control, while rabbits of the 3^rd group were orally given the alcohol extract of Cichorium Intybus in a dose of 400 mg /kg b.wt./ day for 3 weeks. Blood samples were collected at end of the 1^st, 2^nd and 3^rd week for determination of glucose and total cholesterol levels. The obtained results showed that oral administration of alcohol extract of Cichorium Intybus significantly decreased the high blood glucose and toloal cholesterol levels of the treated diabetic rabbits, as compared to the diabetic control group. In conclusion Oral administration of Cichorium Intybus alcohol extract produces antidiabetic and hypocholesterolemic effects in alloxan–diabetic rabbits. Intake of Cichorium Intybus for 3 weeks may be beneficial for patients who suffer from diabetes mellitus accampanied with hypercholesterolemia.