The objective of the current study was to characterize the clinical and pathological findings of actinomycosis in cattle, and to assess their response for treatment. Actinomycosis was clinically diagnosed in nine cattle. The lesions appeared as hard immobile swellings in the mandible and rarely in maxilla. Smears made from crushed granules in pus revealed the presence of sulfur granules that appeared microscopically as club-like rosettes. Hematological and biochemical examinations indicated leukocytosis, neutrophilia, hyperprotenemia, hypoalbuminaemia and hyper gammaglobulinemia. Treatment through parenteral administration of streptomycin at a dose rate of 15mg/kg daily given intramuscularly for 2 weeks was carried out. Surgical intervention through pus aspiration with long sharp needle and washing with normal saline followed by flushing with iodine solution 2%, was also tried. Adjunct therapy of broad-spectrum antibiotic and non-steroidal anti-inflammatory was administered intramuscularly for five days as a post-operative measure. Four out of nine treated cattle (44.4%) were responded for treatment and almost recovered completely within four months.