The study was conducted on 90 random samples (30 for each of muscles, liver and kidney), which were collected from 30 duck carcasses, from different markets of El-Manzala regions in Dakahlia Province, also 30 blood samples from the same duck and 10 water samples (collected from agricultural drainage and Manzala lake). Contamination by cadmium, lead, copper and iron were detected by using Flame Atomic Absorption Spectrophotometer and the results revealed cadmium concentration in kidney, liver and muscle and the values were 0.830, 0.54 and 0.316 ppm respectively. While the lead level contamination were 4.79±3.47±1.56 ppm in liver; muscle and kidney respectively. The copper level in liver; muscle and kidney were 2.82± 2.66±1.94 ppm respectively. Also the iron level in kidney, liver and muscle respectively, were 43.42±23.90±10.44 ppm. Our results showed that, the highest contamination of cadmium level in kidney then in liver, while the highest level of lead level was in liver then in muscle. Meanwhile the values of cadmium, lead, copper and iron were 0.270± 3.56  ±2.74 ± 37.61 ppm in blood serum samples of ducks. Also the results showed that the mean values of cadmium; lead and copper in water samples were 1.158±1.063±1.632 ppm respectively. Cadmium and lead level detected in our results in duck tissues and water may have a critical impact on public health.