This study was carried out on (29740) animals to determine some epidemiological, clinical and preventive measures associated with Caseous lymphadenitis (CLA). The prevalence was (4.87%) in sheep on the basis of clinical examination. The disease prevalence was significantly higher in females (7.52%) than in males (1.09%). The clinical picture appeared in the form of enlargement and abscessation of the superficial lymph nodes. Superficial cervical lymph nodes were the most commonly affected nodes in sheep. The superficial lymph nodes of the anterior body half showed the highest infection rate. The disease was significantly higher in private flocks (5.58%) than in governmental flocks (0.81%).