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171873

ANTINOCICIPTIVE EFFECT OF GINGER EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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Last updated: 23 Jan 2023

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Abstract

Hyperalgesia is one of the major symptoms of diabetic neuropathy in diabetic patients. Streptozotocin (STZ)-induced diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli, and the most commonly employed animal model aspect of painful diabetic neuropathy. This study was designed to evaluate the analgesic effect of oral Ginger extract on formalin-induced nociceptive responses (standard formalin test) in STZ-induced diabetic rats. For this purpose, STZ-diabetic rats were orally given the aqueous extract of Ginger roots in a dose of 200 mg kg-1/day for one month. The results showed that there was an increase in the pain scores in both phases of the test in the diabetic group. It was found out that treatment with Ginger extract significantly reduced blood glucose in diabetic rats and Ginger-treated diabetic rats exhibited a lower pain score for both phases of the test as compared to untreated-diabetic ones. In contrast, sodium salicylate which acts as positive control only reduced pain scores in the second phase. It could be concluded that oral intake of Ginger extract for one month has a therapeutic potential for treating painful diabetic neuropathy.

DOI

10.21608/avmj.2012.171873

Keywords

Key words: Diabetes mellitus, Ginger extract, streptozotocin, Rats

Authors

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Last Name

ABDEL DAIM

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Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University

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Volume

58

Article Issue

132

Related Issue

24336

Issue Date

2012-01-01

Receive Date

2011-11-12

Publish Date

2012-01-01

Page Start

1

Page End

11

Print ISSN

1012-5973

Online ISSN

2314-5226

Link

https://avmj.journals.ekb.eg/article_171873.html

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https://avmj.journals.ekb.eg/service?article_code=171873

Order

21

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

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Article

Created At

23 Jan 2023