The study was conducted on (300) commercial broiler chickens, for Comparison of the effect of Nucleotides and Brewer`s Yeast on specific immunity of infectious bursal disease (IBD) after vaccination. The study has confirmed that there were clear significant variations between control and study groups which added to its feedNucleotides and Brewer`s yeast during all stages of breeding for titers antibodies for IBD (P value = 0.0001). The study has confirmed that there were clear significant variations between the study groups (group1, group2) which added to its feedNucleotides and yeast beer during all stages of breeding for titers antibodies for IBD (P value =  0.001). in comparison with the control group.