The prevalence of calf scour-causing enteropathogens was investigated in the current study using rapid field test. Fecal samples were collected from a total of 124 cattle (Bos indicus) and water buffalo (Bubalus bubalis) calves. Investigated calves were divided into 4 age groups (0–4 days old, 5–14 days old, 15–21 days old and >21 days old). Immuno-chromatographic rapid tests (FASTest® Strips) were used for the detection of Bovine coronavirus, rotavirus, Cryptosporidium parvum and E.coli-K99 (F5) from investigated diarrheic calves. In cattle calves (n= 76), C. parvum was the most frequently encountered infection among all age groups followed by rotavirus with an overall rate of 59.2% and 35.5%, respectively.  In water buffalo calves (n = 48), the highest infection rate was recorded for C. parvum (39.6%) followed by both rotavirus and E.coli (20.8% each) in all age groups with exception of the first age group (0-4 days-old), where the highest infection rate was recorded as E.coli (57.1%) followed by C. parvum (28.6%). In conclusion, C. parvum was reported as the most frequently encountered causative agent among both cattle and water buffalo calves whilst coronavirus infection seemed to be of minor importance in the investigated population. The higher rate of C. parvum infection was recorded among the second age group (5-14 day old) of cattle calves and the forth age group (> 21 day old) of water buffalo calves, whilst  the highest rate of E.coli-K99 (F5) infection was recorded among the first age group (0-4 days) of both cattle and water buffalo calves.