This study was carried out to evaluate the bacterial contamination andprevalenceofSalmonella spp.andBacilluscereus in 150 samples of edible bovine by-products which were collected from different retail butcher's shops in Assiut city. The obtained results revealed that the mean values of  total viable bacterial count (T.V.B.C.) of Tripe, Mombar (Intestine), Lung and Cerebrum (Brain) were 2x10⁵+0.89, 1x10⁵+0.89, 1x10⁵+0.79 and 8x10⁴+1.06 CFU/g, respectively. Wheras, it was indicated that 90 of the examined samples of edible offal (32 Tripe, 29 Mombar, 16 Lung and 13 Cerebrum) were more than 10³ (MPN/g) for total coliform count. Concerning Salmonella spp., 4 samples (2.7%) only were positive for Salmonella spp. Isolated serovars were identified as S. Enteritidis, S. Typhimurium and S. Anatum. Regarding B. cereus, 12 samples (8%) were positive, which included 5 samples of Tripe, 4 samples of Mombar and 3 samples of Cerebrum, while Lung samples were free.  The average count of B. cereus in positive samples was 1.6x10³ CFU/g, where average number in Tripe, Mombar and Cerebrum were 3x10³, 1.4x10³ and 5x10² CFU/g, respectively. The achieved results indicated that consumption of edible bovine by-products such as Tripe, Mombar, Lung and Cerebrum constitute a public health hazard as they may be associated with food poisoning microorganisms such as S. Typhimurium and S. Enteritidis.