40 male albino rats were used for these experimental studies. They were divided equally into 4 groups: the first group was used as control group, the second group was given thyme extract (300 mg/kg b.w) by gastric intubation, the third group was given CdCl₂ (3mg/kg b.w) intraperitoneally while the fourth group were treated by both agents. Cadmium chloride treated rats exhibited microcytic hypochromic anemia and a significant (P ≤ 0.05) increase in total leucocytic count as well as a significant increase in serum urea, creatinine and malondialdehyde. Moreover a significant decrease in serum total proteins, albumin, globulin, A/G ratio and catalase were detected. Histopathologically, marked degenerative changes were observed in renal and testicular tissues in CdCl₂ treated rats along with diminished expression of Bcl-2 (B-cell lymphoma2) in renal tissues. However, thyme extract treatment ameliorated the deleterious effects of CdCl₂ on biochemical parameters, enhanced the endogenous antioxidant status, reduced lipid peroxidation and the lesions in renal tissues. Thyme extract restored the immunohistochemical expression of Bcl-2. However, hematological parameters and sever testicular degeneration were not alleviated by thyme extract. Our findings also demonstrated that thyme extract can alleviate CdCl₂ nephrotoxicity via its potent antioxidant and anti-apoptotic activities.