One hundred forty eight specimens were gathered from sheep and goats, to be inspected for the presence of Eimeria species by fecal analysis. The infection rate was 65.3%, 80%, 63.6% and 85.7 in sheep, goats, lambs and kids respectively. In histopathological examination Eimeria and oocysts were distinguished in the villi of epithelium, crypts and lieberkuhn glands. Eighteen animals were deliberately infested and classified into three groups according to the used anticoccidial drugs to estimate their efficacy. Hematological and biochemical analysis were done before and after treatment trials in all animals. In case of sheep, the sulphadimidine (33.3%) was more effective than amprolium and diclazuril while, the diclazuril has a better effect than amprolium and sulphadimidine (33.3%) in case of goats. All treated animals showed improved results in the hemogram and biochemical profile in comparison to untreated animals.