The study compares the clinical outcome of the use of different topical treatments for oral lesions in cattle suffering from foot and mouth disease (FMD). One hundred diseased cattle, during an outbreak of FMD in Assiut governorate, Egypt, were used in this study. The animals divided into four equal groups. The oral lesions after being washed with physiological saline solution to remove necrotic tissues, were sprayed twice daily by Phenytoin (PHEN group), Bacitracin and Neomycin (BAC-NEO group), Oxytetracycline and Crystal violet (OXY-CRY group), and the lesions leaved without any topical applications (control group). All animals in the four groups treated daily and for 3 consecutive days by the intramuscular injection of both Oxytetracycline as a broad spectrum antibiotics and Flunixin meglumine as antipyretic and anti-inflammatory drugs. It was observed that all animals in PHEN group show complete healing of oral lesions and the animals return to its normal appetite after 4 days whereas animals in BAC-NEO and OXY-CRY groups take a longer time to show improvement. The lesions in control group remain unhealed with bad appetite till the end of the observation period. It is concluded that Phenytoin (Healosol®) has a potent wound healing activity comparable to Bacitracin-Neomycin (Bivatracin®) and Oxytetracycline-Crystal violet (Oxy G®) in treatment of the oral lesions of FMD in cattle.