Saanen goat is one of the highest milk-producing goat breeds and is greater than the other breeds of goats, has a high reproductive yield. The aim of this study was to investigate the relationship between paraoxonase-1 (PON1) activity and lipid mobilisation in periparturient period of Saanen dairy goats. Fifteen Saanen goats (aged 2-3) were selected for the study. Blood samples were collected from each goat on days -21, -14, -7, 0, 7, 14 and 21 relative to parturition. Blood non-esterified fatty acids (NEFA), β-hydroxybutyric acid (BHBA), triglycerides (TG), total cholesterol (CHOL), Low-density lipoprotein (LDL), high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) and Paraoxonase-1 activity (PON1) levels were measured. Triglyceride concentrations decreased significantly (P<0.001) from parturition until day 21 as compare to the values obtained before parturition. Serum HDL concentrations were significantly lower values on days -21, -14 and -7 (P<0.001) compared to values on days 14 and 7. Serum VLDL concentrations increased significantly from parturition until day prepartum 21 as compare to the values obtained before parturition (P<0.001). Serum LDL levels were significantly higher on day -21 and -14 compared to values on days +7 and +14 (P<0.001). Serum BHBA levels significantly higher on days -21 compared to values on days -14, -7,+7 and +14 (P<0.001). Serum NEFA levels significantly lower on days -21 compared on days -14 and parturition. PON-1 and CHOL levels were no statistical difference. In conclusion, although there was no statistical differences, significant changes in levels of PON-1 were occurred in periparturient Saanen goats and PON-1 may be used as biomarker for metabolic and inflammatory-related and or disorders in periparturient goats. Further study should be conducted for better understanding the determine the availability of PON-1 as a marker of oxidative stress and to confirm these findings