The amyloidosis are a group of disorders in which soluble proteins aggregate and deposit extracellular in tissue as insoluble fibrils, causing progressive organ dysfunction. A definitive diagnosis of amyloidosis is based on the histological presence of amyloid substance in tissue specimens. Under light microscope, amyloid substance appears as homogenous pink extracellular deposits in hematoxylin and eosin. On stained sections with Congo red, the extracellular deposits appear orange red in color. In this study, amyloidosis was diagnosed by histopathological examination under light microscope in the liver and kidney tissues from 30 adult dromedary camels (one-humped) collected from a total 50 adult dromedary camels (one-humped) that were presented for slaughter at Draw abattoir in Aswan Governorate between 2018 and 2019. Amyloid deposits in the kidney were located around Bowmans capsule, mesangial areas and peritubular interstitial tissues. Amyloid was also seen in liver were located around blood vessels and along the sinusoids. Concurrent lesions of amyloid in liver include fatty changes, hydropic degeneration and necrosis. Also Concurrent lesions with amyloid in kidneys include proliferative glomerulonephritis and necrosis in tubules.