Abstract In this research, the researchers addressed the role of the quality of the service through the relationship between the organizational genetics and innovation applied to the specialized medical centers in Mansoura University. A proposed model was designed to be used for testing the relationship between the study variables. Also, a survey questionnaire was designed and the SPSS program was used for data analysis, the analyzing tool AMOS was used for analyzing the direct and the indirect relationships with the coefficients of path analysis. The sample size was about 384 items, with a responding rate 100% of the total of the research sample size. The results of statistical analysis proved that there is a positive significant effect of the organizational genetics on innovation through mediating the quality of the service. Therefore, the research results showed of the increased positive significant effect of the organizational genetics on innovation through mediating the quality of the service. Also, The study proved that there is a significant effect of the dimensions of the organizational genetics on the quality of the service except all the decision rights and incentives. Also, there is a significant effect of the services quality on innovation 2 and the significant effect of the organizational g