Abstract: This study examines the mediating role of knowledge sharing in the relation between empowering leadership (manifested by Enhancing the Meaningfulness of Work, Fostering Participation in Decision Making, Expressing Confidence in High Performance and providing Autonomy) and creative performance in Mansoura university. A conceptual framework was developed from literature, and the relations between its variables were constructed and tested using structural equation modeling (SEM). Results indicate that empowering leadership, knowledge sharing, and creative performance are positively correlated. Expressing Confidence in High Performance and providing Autonomy have positive direct effect on knowledge sharing. Also, Enhancing the Meaningfulness of Work, Expressing Confidence in High Performance and knowledge sharing have positive direct effect on creative performance. knowledge sharing has a mediating role in the relation among both Expressing Confidence in High Performance and providing Autonomy and creative performance. This study provides practical and academic recommendations.