Abstract: This study examines the mediating role of psychological safety in the relation between inclusive leadership (manifested by openness, accessibility and availability of a leader) and employee voice behavior (manifested by promotive and prohibitive voice) in imam Abdulrahman bin Faisal university in Saudi Arabia. A conceptual framework was developed from literature, and the relations between its variables were constructed and tested using structural equation modeling (SEM). Results indicate that inclusive leadership, psychological safety and employee voice behavior are positively correlated. Openness and accessibility have positive direct effect on psychological safety. Also, inclusive leadership and psychological safety have positive direct effect on employee voice behavior. Psychological safety has a mediating role in the relation between openness and employee voice behavior. The mediating role of psychological safety in the relation among both accessibility and availability and employee voice behavior is not significant. This study provides practical and academic recommendations