Hotels operate in a highly competitive and continually evolving business environment. They are required constantly to implement various changes and adapt their business operations to keep up with the rapid changes. Therefore, managing organizational change has become crucial to hotel organizations for long-term survival and growth. The research aims to determine the variables impacting the implementation of organizational change management in large Egyptian hotels. A structured questionnaire was designed and used as a research method to gather the data from a sample of employees of large hotels in Egypt that experienced organizational change. This study adopted the Partial Least Squares Structural Equation Modeling technique (PLS-SEM) to analyze and test the research hypotheses. The results identified five factors directly and significantly impacting the implementation of organizational change in large hotels, respectively: employee engagement, leadership support, communication, organizational culture, and employee resistance to change. The study also found that employee engagement partially mediated the effects between these independent variables and the implementation of organizational change. The study implied that change leaders in hotels should adopt a planned approach to organizational change and highly consider the factors resulting in this study to undertake organizational change initiatives successfully.