Objective: To compare the shaping ability of Fanta, One Curve, and Pro Taper Next Ni-Ti rotary file systems. Materials and Methods: Sixty Mandibular molars with mesiobuccal canals with curvatures ranging between 20° and 40° were divided into three groups of 20 teeth each. a group for each system as follows: group 1 was prepared by Fanta file system, group 2 was prepared by Pro Taper Next file system, and group 3 was prepared by One Curve file system. The measuring of canal curvatures was determined by Schneider's method using standardized periapical radiographs and the Image J software. Pre and post-CBCT scans were done on all samples. Measurements of Pre and Post CBCT scans were compared to assess transportation and centering ability. Data were analyzed using the Minitab 19 program one-way analysis of variance (ANOVA) and Tukey Honestly Significant Difference (HSD) test. Results: There was no significant difference between the 3 tested groups regarding transportation or centering ratio, but the coronal third showed higher values of transportation with Fanta group (p≤0.05), and Pro Taper next group (p≤0.05). Conclusions: All instruments were safe to use. The three instruments showed no significant difference regarding shaping ability.