This study was conducted to acquaintance the effectiveness of fresh juices (kiwi and avocado) against indomethacin toxicity in experimental rats. Thirty-six male albino rats (185±10 g) divided into six groups, one kept as a control (-ve) group (6 rats), while other groups 30 rats were treated orally of indomethacin (25mg / kg b.Wt.) once daily for twenty-one (21) days. One group was kept as (+ve) control group, while others given administration of kiwi juice and avocado juice (10 and 20 ml/kg) by orally for 21 days plus Indo. At the end of the experiment, feed intake (FI), body weight gain (BWG %) and feed efficiency ratio (EFR) were calculated. Aspartate aminotransferase (AST), alanine aminotransferase (ALT),creatinine and urea were determined in serum. Red blood cell and white blood cells count were measured. Hemoglobin and hematocrit (HCT) concentration was estimated. Also, histopathological changes for liver were examined. The biochemical and histopathological analysis proved the toxic effects of indomethacin on kidney and liver. The obtained results concluded that using tested juices improved previous mentioned parameters. The best results found by using high doses of each juice. According to the results, tested juices could be used for protection from toxicity caused by indomethacin.