This study aimed to investigate the effect of fortified diet with avocado fruits and zinc chloride of rats suffering from diabetes and osteoporosis. Forty eight female Sprague-Dawley rats were divided into two main groups as follows: The first main group 6 rats fed on basal diet, as a control negative group. The second main group (42 rats) injected with alloxan monohydrate 90 mg/kg body weight to induced hyperglycemia. After 7 days serum glucose was determined in the first and second main groups to insure the induction. Rats in the second main group (diabetic rats) received oral prednisone acetate (4.5 ml/kg body weight/day twice a week) for two weeks to induce osteoporosis. After this period, the rats in the second main group were divided into seven subgroups (n= 6 rats) as follows: Subgroup (1): fed on basal diet (control positive group). Subgroup (2 and 3): were fed on basal diet containing 7.5% and 15% avocado fruits, respectively. Subgroup (4 and 5): were fed on basal diet containing 2g and 4g zinc chloride in the mineral mixture, respectively. Subgroup (6 and 7): were fed on basal diet containing (7.5% avocado fruits and 2g zinc chloride in the mineral mixture) and (15% avocado fruits and 4g zinc chloride in the mineral mixture),respectively. During the experimental period, the diets consumed and body weights were recorded twice weekly. The results showed that, the highest improvement in lipid profile recorded for the groups which were treated with diet containing (15% avocado and 4g zinc chloride in the mineral mixture), 7.5% avocado and 2g zinc chloride in the mineral mixture and 15% avocado, respectively. The highest levels of avocado fruits and zinc chloride together (15% avocado and 4g zinc chloride) recorded the best results in bone status. Serum glucose improved in groups which were treated with (15% avocado and 4g zinc chloride together), followed by the groups treated with  (7.5% avocado and 2g zinc chloride together), and 4g zinc chloride, respectively. Serum and liver zinc increased gradually with increasing the levels of avocado and zinc chloride in the diets. From these results, it could be concluded that, the fortified diet with avocado fruits and zinc chloride improved the nutritional and biochemical parameters of diabetic rats suffering from osteoporosis.