Efficacy of compost, bioagents and some commercial biocides individually or in combination for controlling tomato sclerotinia rot caused by Sclerotinia sclerotiorum (Lib.) de Bary under greenhouse and field conditions were studied. Results indicated that Trichoderma album and Bacillus subtilis were the most effective bioagents in inhibiting mycelial growth of S. sclerotiorum in vitro. All treatments significantly reduced disease incidence and severity of tomato white rot disease compared with untreated control. However, T. album and Pseudomonas fluorescens combined with compost reduced the disease incidence and disease severity from 100 and 77.40 in control to 11.1 & 1.5% and 11.1 & 2.5%, respectively, under greenhouse conditions. The integrated T. album, P. fluorescens and Bio-Zeid with compost recorded the highest increase of fresh weight and dry weight of shoots and roots compared with individual treatments and control. Under field conditions, adding compost to the soil pre-transplanting decreased the percentage of infection and increased yield of tomato plants compared with other treatments with compost. In this respect, the integration between T. album + B. subtilis + Ps. fluorescens and compost was the most effective treatment for reduced the disease incidence and disease severity. As well as, this treatment increased the fruit weight per plant. On the side, all treatments increased the phenols and flavonoids content in tomato plants. The highest increase in the total phenols and flavonoids contents were recorded with T. album, P. fluorescens and Bio-Zeid combined with compost. Also, all treatments increased peroxidase (PO), polyphenoloxidase (PPO), chitinase and β-1, 3- glucanase activities in treated tomato plants. It could be concluded, the combination between compost, bioagents and some commercial biocides might be useful as an useful tool for controlling tomato sclerotinia disease under greenhouses and field conditions.