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142288

The Hepatoprotective Effect of Carrot (Daucus Carota L.) as Antioxidant on Intoxicated rats with Ccl4

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Last updated: 28 Dec 2024

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Abstract

ABSTRACT The effect of feeding dry powder of carrot at three graded concentrations (5,10,20 %) mixed with the basal diet to carbon tetrachloride (Ccl4) intoxicated male rats for 4 weeks was studied. Intoxication  of  rats  was  done  by s/c injection  of Ccl4 (1 ml/kg) in the first (treatment group) and the last (prophylaxis ) two days of feeding period, as a single dose
per day. Results of this study revealed that prophylaxis is more powerful than treatment groups. Both groups significantly increased feed intake, body weight gain percent and feed efficiency ratio. Biochemical analyses cleared that carrot supplementation to diet significantly lowered serum total cholesterol, triglycerides and LDL cholesterol, but increased HDL cholesterol. Serum liver enzymes( AST and ALT) as well as concentrations of urea nitrogen, uric acid and creatinine decreased in rats fed carrot supplemented diet .Histopathological examinations of liver and kidneys of these rats showed a decrease or amelioration of pathological lesions and damages caused by Ccl4 intoxicated rats.

DOI

10.21608/mbse.2007.142288

Authors

First Name

A.M.

Last Name

Attia

MiddleName

-

Affiliation

Nutrition and Food Science Department-Faculty of Home Economics- Helwan University

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Orcid

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First Name

M.A.

Last Name

Shalaby

MiddleName

-

Affiliation

Pharmacology Department- Faculty of Veterinary Medicine- Cairo University

Email

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City

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Orcid

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First Name

B.H.

Last Name

Lotfia

MiddleName

-

Affiliation

Nutrition and Food Science Department-Faculty of Home Economics- Helwan University

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Orcid

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First Name

S.R.

Last Name

Reham

MiddleName

-

Affiliation

* Nutrition and Food Science Department-Faculty of Home Economics- Helwan University

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-

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Orcid

-

Volume

2007

Article Issue

9

Related Issue

20808

Issue Date

2007-01-01

Receive Date

2006-11-08

Publish Date

2007-01-01

Page Start

169

Page End

190

Print ISSN

2314-8683

Online ISSN

2314-8691

Article File

MBSE_Volume 2007_Issue 9_Pages 169-190.pdf

PDF . 370.3kB

Link

https://mbse.journals.ekb.eg/article_142288.html

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https://mbse.journals.ekb.eg/service?article_code=142288

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5

Type

مقالات علمیة محکمة

Type Code

1,632

Publication Type

Journal

Publication Title

مجلة بحوث التربية النوعية

Publication Link

https://mbse.journals.ekb.eg/

MainTitle

The Hepatoprotective Effect of Carrot (Daucus Carota L.) as Antioxidant on Intoxicated rats with Ccl4

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Article

Created At

23 Jan 2023